Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 3

年份

2018 1

2013 1

关键词

检索范围：

排序：展示方式：

Impacts of n-alkane concentration on soil bacterial community structure and alkane monooxygenase genes

Yueqiao Liu, Aizhong Ding, Yujiao Sun, Xuefeng Xia, Dayi Zhang

《环境科学与工程前沿（英文）》 2018年第12卷第5期 doi: 10.1007/s11783-018-1064-5

摘要：

Soil microbial community is not significantly shaped by alkane concentrations

Alkane concentrations alter dominant alkane degraders in soils

Different alkanes are preferentially degraded at different contamination level

Different types of alkane monooxygenase genes responsible for alkane degradation

关键词： Petroleum hydrocarbon contaminated site n-alkane contamination level n-alkane biodegradation Soil bacterial community Alkane degraders Alkane-monooxygenase genes

HTML PDF 收藏

Discovery of small molecule degraders for modulating cell cycle

《医学前沿（英文）》页码 823-854 doi: 10.1007/s11684-023-1027-5

摘要： The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

关键词： PROTAC molecular glue degrader cell cycle CDK cyclin

HTML PDF 收藏

Selective pseudosolubilization capability of

Fei HUA, Hongqi WANG

《环境科学与工程前沿（英文）》 2013年第7卷第4期页码 539-551 doi: 10.1007/s11783-013-0498-z

摘要： Pseudosolubilized ability of sp. DG17 on -alkanes, role of biosurfactants in -octadecane uptake and trans-membrane transport mechanism of -octadecane were studied by analyzing amount of pseudosolubilized oil components in water phase, and the fraction of radiolabeled C -octadecane in the broth and cell pellet. GC-MS results showed that pseudosolubilized oil components were mainly C to C of -alkanes. In -octadecane broth, pseudosolubilized -octadecane could be accumulated as long as pseudosolubilized rate was faster than mineralization rate of substrate, and the maximum concentration of pseudosolubilized -octadecane achieved to 45.37 mg·L . All of these results showed that sp. DG17 mainly utilized alkanes by directly contacting with pseudosolubilized small oil droplets in the water phase. Analysis of C amount in cell pellet revealed that an energy-dependent system mainly controlled the trans-membrane transport of -octadecane.

关键词： Pseudomonas alkane uptake pseudosolubilization trans-membrane transport